Improving Outcomes After Blood and Marrow Transplants
Blood and Marrow Transplant Clinical Trials Network
This network helps find better ways to care for people receiving blood and marrow transplants, especially focusing on preventing complications like graft-versus-host disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11169088 on NIH RePORTER |
What this research studies
This research network brings together several transplant centers to conduct important clinical trials. One key trial is looking at whether a dietary supplement called galactooligosaccharide (GOS) can help patients after an allogeneic stem cell transplant. We know that the balance of bacteria in the gut, called the microbiome, is important for recovery after transplant. This trial aims to see if GOS, which is already available as a supplement, can improve patient outcomes by positively influencing the gut microbiome.
Who could benefit from this research
Good fit: Ideal candidates would be individuals undergoing an allogeneic hematopoietic stem cell transplant who are at risk for complications like acute graft-versus-host disease.
Not a fit: Patients not undergoing an allogeneic hematopoietic stem cell transplant or those without risk factors for acute graft-versus-host disease may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or reduce serious complications like acute graft-versus-host disease after a blood and marrow transplant.
How similar studies have performed: Previous laboratory and patient data suggest a connection between gut bacteria and transplant outcomes, providing a basis for this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Horwitz, Mitchell E — Duke University
- Study coordinator: Horwitz, Mitchell E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.