Improving motivation in older adults with depression using digital tools

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

NIH-funded research Adventhealth Orlando · NIH-11086146

This study is looking for older adults with late-life depression who feel unmotivated, to see if special online brain exercises can help boost their motivation and improve their overall mental health.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionAdventhealth Orlando NIH-funded
Lab location1 site (Orlando, United States)
Project IDNIH-11086146 on NIH RePORTER

What this research studies

This research focuses on addressing apathy, a common and debilitating symptom in older adults suffering from late-life depression. The study aims to evaluate how customized digital cognitive training can target specific brain networks associated with motivation and cognitive function. By conducting a randomized controlled trial, the researchers will assess the effectiveness of this non-pharmacologic intervention in reducing apathy and improving overall mental health outcomes for older adults. Participants will engage in tailored digital exercises designed to enhance their motivation and cognitive abilities.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults diagnosed with major depressive disorder who experience significant apathy.

Not a fit: Patients who do not have major depressive disorder or those without symptoms of apathy may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective, non-drug treatments for apathy in older adults with depression, improving their quality of life.

How similar studies have performed: Previous research has shown promise in using digital interventions for cognitive and motivational enhancement, suggesting potential success for this approach.

Where this research is happening

Orlando, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Affective Disorders
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.