Improving Mass Spectrometry for Detailed Tissue Imaging
Development and Application of New Ionization Methods for Biological Mass Spectrometry
This project is creating advanced imaging tools using mass spectrometry to get a clearer picture of what happens in tissues affected by conditions like stroke and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-11044192 on NIH RePORTER |
What this research studies
This project focuses on making mass spectrometry, a powerful tool for understanding molecules, even better. Researchers are developing new techniques to prepare biological samples so that they can create very detailed images of tissues. By applying these new imaging methods to model organisms, the goal is to uncover the specific changes that occur in conditions such as ischemic stroke, wound healing, and cardiometabolic disease. Ultimately, this work aims to provide a clearer molecular understanding of various human health issues.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this technology could benefit patients with conditions like ischemic stroke, wound healing issues, or cardiometabolic disease.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this early-stage technology development.
Why it matters
Potential benefit: If successful, this could lead to a deeper understanding of how diseases affect tissues at a molecular level, potentially paving the way for new diagnostic tools or treatments.
How similar studies have performed: Mass spectrometry is a well-established technique, but these new ionization methods for tissue imaging represent an innovative advancement in the field.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Muddiman, David C. — North Carolina State University Raleigh
- Study coordinator: Muddiman, David C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.