Improving lung function in people with HIV and cigarette smoke exposure
Restoring mucociliary clearance apparatus to mitigate lung inflammation in the context of HIV and cigarette smoke
This study is looking at how HIV and cigarette smoke can cause lung problems, like inflammation and mucus buildup, and it aims to find new ways to help improve lung health for people affected by these issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10664021 on NIH RePORTER |
What this research studies
This research investigates how HIV and cigarette smoke contribute to lung inflammation and impaired mucociliary clearance, which is essential for lung health. It focuses on the role of a specific protein from HIV that disrupts cellular processes, leading to mucus buildup and increased risk of lung infections. By using advanced gene-editing techniques, the study aims to restore normal function to the mucociliary system, potentially improving lung health for affected individuals. Patients may be involved in trials that explore these innovative treatments and their effects on lung function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of cigarette smoking and experience lung-related issues.
Not a fit: Patients without HIV or those who do not smoke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung function and reduce inflammation in patients with HIV and a history of smoking.
How similar studies have performed: Previous research has shown promise in using gene-editing techniques to address similar lung function issues, indicating potential for success in this approach.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Chinnapaiyan, Srinivasan — Florida International University
- Study coordinator: Chinnapaiyan, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.