Improving limb function after lower limb loss with a new surgical technique
Official title: Quantifying Locomotor Outcomes with Agonist-Antagonist Myoneural Interface
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-10816732 · Data updated 2026-11-12
This study is looking at a new surgical method that helps people with lower limb loss use their prosthetic legs more naturally and effectively, aiming to improve their walking and overall mobility.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $240,722 |
| NIH project number | 1R03HD114176-01 |
| Project ID | NIH-10816732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone lower limb amputation and are using or are candidates for prosthetic limbs.
✕Less likely to help
Patients who have not experienced lower limb loss or those who are not using prosthetic devices may not benefit from this research.
What this research studies
This research investigates a novel surgical approach called the agonist-antagonist myoneural interface (AMI), which aims to enhance the function of residual limbs in individuals who have experienced lower limb loss. By restoring the natural dynamics between paired muscles, the AMI technique seeks to improve sensory feedback and control of muscle-driven prostheses. The study will assess how this technique affects walking and recovery from disturbances while using conventional prosthetics, potentially leading to better mobility outcomes for patients.
Why it matters
Potential benefit: If successful, this research could significantly enhance the control and functionality of prosthetic limbs for individuals with lower limb amputations.
How similar studies have gone: While the AMI technique is innovative, initial work suggests it may build on existing knowledge of muscle dynamics and prosthetic control, indicating potential for success.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Butowicz, Courtney M. — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Butowicz, Courtney M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.