Improving inflammation resolution to support bone marrow recovery
Official title: Improving Inflammation Resolution to Mitigate Acquired Bone Marrow Failure
Funded at Albany Medical College · NIH-11333205 · Data updated 2026-11-12
A research project tests new ways to help the body finish healing from inflammation in people with acquired bone marrow failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $483,920 |
| NIH project number | 5R01HL159411-04 |
| Project ID | NIH-11333205 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with acquired bone marrow failure related to autoimmune processes, especially where current treatments are limited by age or intolerance.
✕Less likely to help
Patients without inflammatory bone marrow issues or those who do not fit the disease model may not benefit.
What this research studies
This project uses a mouse model of severe aplastic anemia to study how the body resolves inflammation and promotes repair. It builds on preliminary findings that special resolving molecules may improve disease by supporting bone marrow recovery. The team plans to explore therapies that shift the balance toward inflammation resolution rather than simply dampening immune responses. If successful, the work could point to new approaches to help older patients tolerate treatments and improve blood cell production.
Why it matters
Potential benefit: If successful, the research could lead to new therapies that improve bone marrow recovery and reduce treatment-related complications, especially in older patients.
How similar studies have gone: Preliminary work in this area suggests that promoting inflammation resolution can improve bone marrow function in this disease model.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Macnamara, Katherine C — Albany Medical College
- Study coordinator: Macnamara, Katherine C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.