Improving how we measure the effectiveness of brain drugs
Official title: Improved drug efficacy assessment using joint Bayesian estimation framework
Funded at Yale University · NIH-11089402 · Data updated 2026-11-12
This study is looking at how well new drugs work in the brain by using special scans to see how they interact with brain receptors, which could help make medications more effective for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 17, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $387,830 |
| NIH project number | 5R01EB035093-02 |
| Project ID | NIH-11089402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with central nervous system disorders who are participating in clinical trials for new CNS drugs.
✕Less likely to help
Patients with conditions unrelated to central nervous system disorders may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the assessment of drug efficacy in the central nervous system using advanced imaging techniques. By employing positron emission tomography (PET) scans, the study aims to quantify how well drugs engage with their target receptors in the brain. The innovative approach involves jointly estimating receptor occupancy and drug concentration effects, which could lead to more precise measurements compared to traditional methods. Patients may benefit from improved drug development processes that ensure medications are more effective and tailored to their needs.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for central nervous system disorders by providing better drug efficacy assessments.
How similar studies have gone: Previous research has shown promise in using PET imaging for drug efficacy assessment, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Marin, Thibault — Yale University
- Study coordinator: Marin, Thibault
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.