Improving HIV prevention methods using new data approaches
Official title: Combining sources of information to improve HIV pre-exposure prophylaxis
Funded at Univ of North Carolina Chapel Hill · NIH-10895580 · Data updated 2026-11-12
This study is looking at how to make HIV prevention methods, like daily pills and long-lasting injections, work better for different groups of people, including men who have sex with men, transgender women, and cisgender women, by using past data to find the best options without needing to run traditional trials.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 28, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $136,327 |
| NIH project number | 5K01AI177102-02 |
| Project ID | NIH-10895580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men who have sex with men, transgender women, and cisgender women who are at risk of HIV exposure.
✕Less likely to help
Patients who are not at risk for HIV or those who are already on effective HIV prevention methods may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of HIV pre-exposure prophylaxis (PrEP) by integrating various data sources to evaluate new treatment combinations. It aims to overcome challenges in traditional randomized trials, such as strict eligibility criteria and sample size limitations. By analyzing data from previous trials and employing advanced statistical methods, the research will assess the efficacy of long-acting injectable cabotegravir and daily oral PrEP among different populations, including men who have sex with men, transgender women, and cisgender women. This innovative approach seeks to provide reliable estimates of treatment effectiveness without the need for direct comparisons.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible HIV prevention strategies, ultimately reducing the incidence of HIV infections.
How similar studies have gone: Previous research has shown promise in using innovative analytical methods to evaluate HIV prevention strategies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Zivich, Paul Nicholas — Univ of North Carolina Chapel Hill
- Study coordinator: Zivich, Paul Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.