Improving heart function during mechanical support for heart failure patients
Official title: Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support
Funded at Massachusetts Institute of Technology · NIH-10988236 · Data updated 2026-11-12
This study is looking at how the two sides of the heart work together when patients with severe heart failure need mechanical support, with the hope of finding better ways to help them feel better and improve their treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 1, 2023 |
| Project end | January 15, 2025 |
| Funding year | 2025 |
| Award (this year) | $13,300 |
| NIH project number | 5F31HL170537-02 |
| Project ID | NIH-10988236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from severe heart failure or cardiogenic shock who may require mechanical circulatory support.
✕Less likely to help
Patients with stable heart function or those not requiring mechanical support may not benefit from this research.
What this research studies
This research investigates how the left and right sides of the heart work together during mechanical support for patients experiencing cardiogenic shock, a severe form of heart failure. By using a novel animal model, the study aims to understand the interactions between the two ventricles and how these interactions affect patient outcomes when using mechanical devices. The goal is to identify key metrics that can guide the selection and adjustment of these devices to improve heart function and patient tolerance. This research could lead to better treatment strategies for patients with severe heart conditions.
Why it matters
Potential benefit: If successful, this research could significantly enhance the effectiveness of mechanical circulatory support for patients with heart failure, potentially improving survival rates and quality of life.
How similar studies have gone: Previous research has shown promise in understanding heart function dynamics during mechanical support, but this specific approach to right-left ventricular coupling is relatively novel.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Lamberti, Kimberly K — Massachusetts Institute of Technology
- Study coordinator: Lamberti, Kimberly K
Related research
Other NIH-funded projects on the same topics.
-
PhysioNet: A trusted, open data repository for clinical and physiological data
A publicly accessible platform provides curated clinical and physiological data and tools to help researchers develop and test AI models for better healthcare.
-
Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate
Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.
-
Single-cell, label-free mapping of senescence in tissues with Raman imaging and spatial genomics
A project to map how senescent cells differ across tissues using a noninvasive Raman imaging method combined with spatial genomics.
-
Structures and dynamics of virus ion channels
This project studies the tiny channels in certain influenza and coronavirus viruses to understand how they let ions pass through and contribute to disease.
-
Prospect: Stem Cell Models for Early-Onset Colorectal Cancer Prevention
Researchers at MIT are using stem cell models to understand why colorectal cancer is rising in people under 50 and how to prevent it.
-
MATCHMAKERS: AI tools to predict TCR binding and design
Researchers are building AI tools to predict how T cell receptors recognize tumor antigens, with aims to help improve targeted immunotherapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.