Improving heart function after transplantation using a new technique
Protection of transplanted heart function by regulation of Na/K pump activity
This study is testing a new method to help keep donor hearts healthy while they are stored, so they work better when transplanted into patients, ultimately aiming to make more hearts available for those in need of a transplant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wr Biotech, LLC NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10691960 on NIH RePORTER |
What this research studies
This research investigates a novel technique called improved Synchronization Modulation Electric Field (i-SMEF) to protect donor hearts and enhance the function of transplanted grafts. The i-SMEF will be applied to donor hearts during cold storage, and the effectiveness will be evaluated in mice after heart transplantation. The goal is to address the challenges of ischemia reperfusion injury, which can lead to graft failure and mortality. By extending the storage time of donor hearts, this research aims to increase the availability of viable organs for transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with advanced-stage heart failure or complex congenital heart disease who may require a heart transplant.
Not a fit: Patients who are not candidates for heart transplantation or those with conditions unrelated to heart function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart transplant outcomes and longer-lasting graft function for patients.
How similar studies have performed: While the approach is innovative, similar techniques have shown promise in improving organ preservation and transplant outcomes in preliminary studies.
Where this research is happening
Tampa, United States
- Wr Biotech, LLC — Tampa, United States (Active)
Researchers
- Principal investigator: Liu, Ruisheng — Wr Biotech, LLC
- Study coordinator: Liu, Ruisheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.