Protecting donor kidneys using electric fields
Protection of donor kidneys with synchronization modulation electric field (SMEF)
['FUNDING_OTHER'] · WR BIOTECH, LLC · NIH-10705847
This study is testing a new method to help keep donor kidneys healthy while they are stored, using a special electric field to prevent damage, and it’s being done with adult pigs to see how well it works before using it in human transplants.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WR BIOTECH, LLC (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10705847 on ClinicalTrials.gov |
What this research studies
This research investigates a novel technique called improved Synchronization Modulation Electric Field (i-SMEF) to protect donor kidneys from damage during cold storage. By applying this electric field, the research aims to enhance the function of transplanted kidneys by preventing ischemic injury, which occurs when blood supply is restricted. The study will utilize adult Yorkshire pigs as a preclinical model to evaluate the effectiveness of i-SMEF in maintaining kidney function during transplantation. The approach focuses on optimizing the parameters of the electric field to ensure maximum protection for the kidneys.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing kidney transplantation or have a need for kidney grafts.
Not a fit: Patients who are not candidates for kidney transplantation or those with non-renal conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for kidney transplant patients by enhancing the viability and function of donor kidneys.
How similar studies have performed: Previous research has shown promising results with similar techniques in animal models, indicating potential for success in this novel approach.
Where this research is happening
TAMPA, UNITED STATES
- WR BIOTECH, LLC — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, RUISHENG — WR BIOTECH, LLC
- Study coordinator: LIU, RUISHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.