Improving healing of soft tissues to bone using a new growth factor.
Enhanced Soft Tissue-to-Bone Healing via Treatment with Novel Growth Factor NELL-1: Targeted Delivery and Biomimetic Scaffolds
This study is looking at a new way to help heal soft tissues like tendons and ligaments that connect to bone, using a special growth factor called NELL-1, to improve recovery for people with common injuries like ACL tears and rotator cuff problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10881768 on NIH RePORTER |
What this research studies
This research focuses on enhancing the healing process of soft tissues, such as tendons and ligaments, to bone using a novel growth factor called NELL-1. The approach involves developing targeted delivery methods and biomimetic scaffolds that mimic natural tissue structures. By conducting preclinical assessments and eventually clinical trials, the research aims to improve surgical outcomes for patients with musculoskeletal injuries, particularly those involving the anterior cruciate ligament (ACL) and rotator cuff. The goal is to provide better treatment options for individuals suffering from these common injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with ACL injuries or rotator cuff tears who may require surgical intervention.
Not a fit: Patients with soft tissue injuries that do not require surgical treatment or those with other unrelated musculoskeletal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for soft tissue injuries, reducing recovery time and improving overall patient outcomes.
How similar studies have performed: Previous research has shown promise in using growth factors and biomimetic scaffolds for tissue healing, indicating potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kremen, Thomas John — VA Greater Los Angeles Healthcare System
- Study coordinator: Kremen, Thomas John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.