Improving healing for complex limb injuries
Official title: Regenerative engineering for complex extremity trauma
Funded at Oregon Health & Science University · NIH-10990549 · Data updated 2026-11-12
This study is exploring new ways to help people with serious limb injuries heal better by using special materials and exercise to boost the body's natural ability to repair muscle and bone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $455,481 |
| NIH project number | 5R01AR080150-03 |
| Project ID | NIH-10990549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from severe extremity trauma that involves both muscle and bone injuries.
✕Less likely to help
Patients with isolated soft tissue injuries or those who do not have significant muscle or bone damage may not benefit from this research.
What this research studies
This research focuses on developing new regenerative therapies for patients with severe limb injuries that involve both muscle and bone damage. The approach combines advanced materials that mimic natural tissue structures with exercise to enhance healing. By using nanoscale patterns in scaffolds, the study aims to improve the body's ability to regenerate muscle and bone, potentially leading to better recovery outcomes for patients. The research also investigates how muscle cells can influence bone healing, which is crucial for restoring limb function.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with complex limb injuries, reducing the need for multiple surgeries and improving recovery times.
How similar studies have gone: Previous research has shown promising results using similar regenerative approaches, indicating potential for success in this area.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Nakayama, Karina — Oregon Health & Science University
- Study coordinator: Nakayama, Karina
Related research
Other NIH-funded projects on the same topics.
-
Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
-
Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
-
Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
-
Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
-
Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
-
Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.