Improving Gene Editing in Patient Cells
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
This project aims to learn how gene editing tools work better in cells from patients, so we can make them more effective for future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11088766 on NIH RePORTER |
What this research studies
This project looks closely at how gene editing, using tools like CRISPR, changes genes in cells taken from patients. We want to understand why these tools sometimes work well and sometimes don't, and how they affect the cells' normal functions. By watching gene editing happen in real-time with specially designed particles, we hope to find ways to make these "genome surgery" techniques more precise and reliable for human cells and tissues. This deeper understanding could lead to better and safer gene therapies in the future.
Who could benefit from this research
Good fit: This foundational research uses patient-derived cells, meaning individuals with specific conditions might contribute samples to similar future efforts, but direct patient participation in this specific grant is not described.
Not a fit: Patients seeking immediate therapeutic intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to more effective and safer gene editing treatments for various human diseases by improving our understanding of how these tools work in patient cells.
How similar studies have performed: While CRISPR technology is well-established, this specific approach of systematically assembling and observing novel gene editing particles in patient-derived cells to understand bottlenecks is a novel research direction.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Saha, Krishanu — University of Wisconsin-Madison
- Study coordinator: Saha, Krishanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.