Improving exercise rehabilitation for Veterans with peripheral artery disease
Improving exercise rehabilitation efficacy and outcomes in Veterans with peripheral artery disease: Targeting oxidative stress and inflammation
This study is looking to improve exercise rehabilitation for Veterans with peripheral artery disease (PAD) by understanding how factors like oxidative stress and inflammation affect their ability to exercise, so we can create better treatments that help them get moving again.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10869935 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of exercise rehabilitation for Veterans suffering from peripheral artery disease (PAD), a condition that severely limits blood flow and exercise tolerance. The study aims to identify the underlying mechanisms of exercise intolerance, particularly the roles of oxidative stress and inflammation in PAD. By investigating these factors, the research seeks to develop targeted interventions that can improve blood flow and mitochondrial function, ultimately leading to better rehabilitation outcomes for patients. Veterans, who are at a higher risk for PAD due to various health factors, will be the primary focus of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans diagnosed with peripheral artery disease who experience exercise intolerance.
Not a fit: Patients without peripheral artery disease or those who do not have a history of cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life and exercise capacity for Veterans with peripheral artery disease.
How similar studies have performed: Previous research has shown that targeting oxidative stress and inflammation can lead to improved outcomes in similar patient populations, suggesting a promising avenue for this investigation.
Where this research is happening
Salt Lake City, United States
- VA Salt Lake City Healthcare System — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Craig, Jesse Charles — VA Salt Lake City Healthcare System
- Study coordinator: Craig, Jesse Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.