Improving exercise rehabilitation for Veterans with peripheral artery disease

Who could benefit from this research

What this research studies

This research focuses on enhancing the effectiveness of exercise rehabilitation for Veterans suffering from peripheral artery disease (PAD), a condition that severely limits blood flow and exercise tolerance. The study aims to identify the underlying mechanisms of exercise intolerance, particularly the roles of oxidative stress and inflammation in PAD. By investigating these factors, the research seeks to develop targeted interventions that can improve blood flow and mitochondrial function, ultimately leading to better rehabilitation outcomes for patients. Veterans, who are at a higher risk for PAD due to various health factors, will be the primary focus of this investigation.

Why it matters

Where this research is happening

• VA Salt Lake City Healthcare System
  Salt Lake City, United States Active

Researchers

• Principal investigator: Craig, Jesse Charles — VA Salt Lake City Healthcare System
• Study coordinator: Craig, Jesse Charles

Related research

Other NIH-funded projects on the same topics.

• Investigating how microRNA-210 affects oxidative stress in patients with peripheral artery disease

  This study is looking at how a tiny molecule called microRNA-210 affects muscle health in people with peripheral artery disease (PAD) and how it might help doctors create better, personalized treatments for patients after they have surgery to improve blood flow.

  NIH research University of West Florida · Pensacola, United States · NIH-11220628

• Low-dose colchicine to reduce vascular risk in people with peripheral artery disease

  This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.

  NIH research Duke University · Durham, United States · NIH-11624874

• How vitamin B12 helps the gum-disease bacterium survive

  Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.

  NIH research University of Louisville · Louisville, United States · NIH-11506468

• Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life

  A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11449859

• Pancreatic beta cells, oxidative stress, and gestational diabetes

  A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11449183

• Environmental air pollutants linked to preeclampsia risk in pregnancy

  This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11449018

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.