Improving executive functioning in adolescents with epilepsy using an e-health intervention
Official title: A Phase 3 clinical trial of an e-health behavioral intervention to improve executive functioning in adolescents with epilepsy
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11081926 · Data updated 2026-11-12
This study is testing a new online program called Epilepsy Journey to help teenagers with epilepsy improve their thinking and planning skills, and it includes fun learning activities and virtual sessions to make life a little easier and better for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,907,458 |
| NIH project number | 4UH3NS129558-02 |
| Project ID | NIH-11081926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 12 to 21 who have been diagnosed with epilepsy and are experiencing difficulties with executive functioning.
✕Less likely to help
Patients who do not have epilepsy or those who are outside the age range of 12 to 21 may not benefit from this research.
What this research studies
This research investigates a new e-health behavioral intervention designed to enhance executive functioning in adolescents with epilepsy. The intervention, called Epilepsy Journey, includes ten self-guided learning modules and ten telehealth sessions aimed at improving skills such as problem-solving, organization, and self-regulation. By participating, adolescents will engage in a structured program that has shown promise in improving neurobehavioral functioning and quality of life. The study aims to confirm these benefits through a larger randomized clinical trial.
Why it matters
Potential benefit: If successful, this research could significantly improve the cognitive and behavioral outcomes for adolescents with epilepsy, leading to better academic and social functioning.
How similar studies have gone: Previous smaller trials have shown promising results for similar behavioral interventions, indicating potential for success in this larger study.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Modi, Avani C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Modi, Avani C
Related research
Other NIH-funded projects on the same topics.
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Scaling Up Task-Shifted Epilepsy Care for Children in Africa
A study to help children with epilepsy in Africa get diagnosed and receive seizure care through trained community health workers.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
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Epilepsy Data Ecosystem: A Big-Data Sharing Platform for Better Care
A national effort to collect and share large, multi‑modal brain data from people with medication‑resistant epilepsy to speed discoveries and improve treatment options.
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Exploring epilepsy genes in zebrafish to understand human brain seizures
A study in zebrafish will model human epilepsy genes to help explain how certain brain mutations contribute to seizures.
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New MRI tools to better plan pediatric epilepsy surgery
A new MRI-based approach helps doctors decide the best time to surgically remove brain tissue in children with difficult-to-control seizures.
-
Sahel Epilepsy Study: finding patterns in epilepsy in rural Africa and its links to genes
A plan to study epilepsy in rural Nigeria to discover how common it is, what factors affect risk, and how genetics may influence it, with results that could improve care for people with epilepsy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.