Improving detection of cell interactions in complex biological systems
Accurate interaction detection in combinatorial screens with complex phenotypes
This study is working on a new way to better understand how different factors inside cells interact with each other, which could help find new drug targets for treating diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11092680 on NIH RePORTER |
What this research studies
This research focuses on enhancing the detection of interactions between different biological factors in cells, particularly when analyzing complex traits. By developing a new model called DENIM, the project aims to create a more accurate way to understand how various perturbations affect cell behavior. This involves using advanced techniques like single-cell omics and automated microscopy to analyze high-dimensional data, which can reveal intricate patterns in cellular responses. The ultimate goal is to improve the identification of potential drug targets by better understanding these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve complex cellular interactions, such as cancer or genetic disorders.
Not a fit: Patients with conditions that do not involve significant cellular interaction complexities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug development by accurately identifying how different compounds interact with cellular pathways.
How similar studies have performed: Previous research has shown promise in using advanced modeling techniques for understanding cellular interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Rao, Lee — University of California, San Francisco
- Study coordinator: Rao, Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.