Improving dental restorations using natural compounds from dentin.
Official title: Dentin Biomodification for Optimization of Bioadhesive Dental Restorations
Funded at University of Illinois at Chicago · NIH-10874883 · Data updated 2026-11-12
This study is looking at how natural compounds from teeth can help make dental fillings and crowns last longer and stick better, which could mean fewer trips to the dentist for repairs and a healthier smile for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 24, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $495,973 |
| NIH project number | 7R01DE028194-06 |
| Project ID | NIH-10874883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring dental restorations, particularly those with a history of restoration failures or secondary caries.
✕Less likely to help
Patients who do not require dental restorations or have no history of dental decay may not benefit from this research.
What this research studies
This research focuses on enhancing the longevity and effectiveness of dental restorations by using natural compounds called proanthocyanidins (PACs) derived from dentin. These compounds aim to improve the adhesion between dental materials and tooth structures, potentially reducing the risk of secondary caries, which is a common reason for restoration failure. By mimicking the natural properties of dentin, the study seeks to create more durable and biocompatible dental materials. Patients may benefit from longer-lasting dental restorations and reduced need for repeat procedures.
Why it matters
Potential benefit: If successful, this research could lead to dental restorations that last significantly longer, reducing the need for costly and invasive repeat treatments.
How similar studies have gone: Previous research has shown promise in using natural compounds to enhance dental materials, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bedran-Russo, Ana Karina B — University of Illinois at Chicago
- Study coordinator: Bedran-Russo, Ana Karina B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.