Improving dental restorations using natural compounds from dentin.
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations
This study is looking at how natural compounds from teeth can help make dental fillings and crowns last longer and stick better, which could mean fewer trips to the dentist for repairs and a healthier smile for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10874883 on NIH RePORTER |
What this research studies
This research focuses on enhancing the longevity and effectiveness of dental restorations by using natural compounds called proanthocyanidins (PACs) derived from dentin. These compounds aim to improve the adhesion between dental materials and tooth structures, potentially reducing the risk of secondary caries, which is a common reason for restoration failure. By mimicking the natural properties of dentin, the study seeks to create more durable and biocompatible dental materials. Patients may benefit from longer-lasting dental restorations and reduced need for repeat procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring dental restorations, particularly those with a history of restoration failures or secondary caries.
Not a fit: Patients who do not require dental restorations or have no history of dental decay may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dental restorations that last significantly longer, reducing the need for costly and invasive repeat treatments.
How similar studies have performed: Previous research has shown promise in using natural compounds to enhance dental materials, indicating a potential for success in this novel approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Bedran-Russo, Ana Karina B — University of Illinois at Chicago
- Study coordinator: Bedran-Russo, Ana Karina B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.