Improving brain tumor treatment with advanced FLASH radiotherapy
Increasing the therapeutic index of brain tumor treatment through innovative FLASH radiotherapy
This study is testing a new way to give radiation therapy for brain tumors that might be kinder to healthy tissues while still fighting the tumor, and it's for dogs with glioblastoma to see how well it works compared to traditional treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10891680 on NIH RePORTER |
What this research studies
This research focuses on a new method of delivering radiation therapy for brain tumors called FLASH radiotherapy, which uses ultra high dose rates. The goal is to reduce damage to healthy tissues while effectively controlling tumor growth. The research involves preclinical studies in animal models and a clinical trial with dogs diagnosed with glioblastoma to assess the benefits of this innovative treatment. By comparing FLASH radiotherapy to conventional methods, the researchers aim to understand its effects on tumor control and cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for participation include dogs diagnosed with glioblastoma and potentially human patients with similar brain tumor conditions in future studies.
Not a fit: Patients with brain tumors that are not glioblastoma or those who are not eligible for radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for brain tumors, improving patient outcomes.
How similar studies have performed: While FLASH radiotherapy is a novel approach, preliminary studies have shown promising results in animal models, indicating potential for success in clinical applications.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Limoli, Charles — University of California-Irvine
- Study coordinator: Limoli, Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.