Improving brain imaging techniques for mice
Official title: SORDINO-fMRI for mouse brain applications
Funded at Univ of North Carolina Chapel Hill · NIH-10894102 · Data updated 2026-11-12
This study is testing a new imaging method called SORDINO to help scientists get clearer pictures of mouse brain activity, which could lead to better understanding of brain function and its effects on human health, especially in research involving anesthesia and stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $609,429 |
| NIH project number | 5R01EB033790-02 |
| Project ID | NIH-10894102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are researchers and scientists working with rodent models in neuroscience and related fields.
✕Less likely to help
Patients who are not involved in animal research or do not work with rodent models will not benefit from this research.
What this research studies
This research focuses on developing a new imaging technique called SORDINO that aims to enhance the quality of functional magnetic resonance imaging (fMRI) for mouse brains. By addressing common issues such as high noise levels and motion artifacts, this technique could provide clearer and more accurate images of brain activity. The study will validate and disseminate this innovative approach to benefit the preclinical animal fMRI community, particularly in studies involving anesthesia and stress. The goal is to improve the understanding of brain function in mice, which can have implications for human health.
Why it matters
Potential benefit: If successful, this research could lead to more precise brain imaging techniques that enhance our understanding of neurological conditions and improve preclinical studies.
How similar studies have gone: While the SORDINO technique is novel, similar advancements in imaging techniques have shown promise in improving the quality of brain imaging in other contexts.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Shih, Yen-Yu Ian — Univ of North Carolina Chapel Hill
- Study coordinator: Shih, Yen-Yu Ian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.