Improving Antibiotic Treatments for Long-Term Infections
Official title: Strategies for improving the efficacy of combinatorial antibiotic therapy in chronic infections
Funded at Texas Tech University · NIH-11097281 · Data updated 2026-11-12
This project looks for better ways to use combinations of antibiotics to fight stubborn, long-lasting infections that are hard to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $349,401 |
| NIH project number | 5R01AI173686-03 |
| Project ID | NIH-11097281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic bacterial infections, especially those in wounds or lungs, who have experienced difficulty with current antibiotic treatments, might eventually benefit from this research.
✕Less likely to help
Patients without chronic bacterial infections or those whose infections are easily cleared by existing treatments may not directly benefit from this specific research.
What this research studies
The spread of antibiotic resistance is a growing concern, especially for chronic infections like those in wounds and lungs. This research aims to understand why current antibiotic treatments often fail against these persistent infections. We will explore how bacteria evolve resistance and how different types of bacteria interact within an infection, which can make treatments less effective. By understanding these complex factors, we hope to design new and more powerful antibiotic combinations to clear these difficult infections.
Why it matters
Potential benefit: If successful, this work could lead to more effective antibiotic treatments for chronic infections, helping patients recover fully and reducing the risk of antibiotic resistance.
How similar studies have gone: While combination antibiotic therapies are common, this research focuses on novel strategies to overcome resistance in chronic infections, suggesting a new or refined approach.
Where this research is happening
-
Texas Tech University
Lubbock, United States Active
Researchers
- Principal investigator: Wakeman, Catherine Ann — Texas Tech University
- Study coordinator: Wakeman, Catherine Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.