Impact of SIRPalpha differences on stem cell transplant outcomes
Effect of SIRPalpha mismatch on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA matched related donor
['FUNDING_R03'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11052538
This study is looking at how differences in a protein called SIRPα between blood cancer patients and their stem cell donors can affect the success of their transplants, with the goal of finding ways to improve transplant outcomes and help patients live healthier lives.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11052538 on ClinicalTrials.gov |
What this research studies
This research investigates how mismatches in a specific protein called SIRPα between donors and recipients affect the success of allogeneic hematopoietic stem cell transplantation (HSCT) for patients with blood cancers. The study aims to understand the role of the innate immune system in recognizing these mismatches and how they influence the risk of complications like graft-versus-host disease (GVHD). By analyzing patient samples and transplant outcomes, the researchers hope to identify factors that could improve transplant success rates and patient survival. This could lead to better matching strategies for donors and recipients in future transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with hematologic malignancies who are undergoing allogeneic HSCT from HLA-matched related donors.
Not a fit: Patients who are not undergoing HSCT or those receiving transplants from unrelated donors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes and reduced complications for patients undergoing stem cell transplants.
How similar studies have performed: Previous research has shown that understanding immune system interactions can significantly impact transplant outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZOU, JUN — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: ZOU, JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Graft Versus Host Disease, acute graft vs host disease, acute graft vs. host disease, acute myeloid leukemia/myelodysplastic syndrome