Impact of SIRPalpha differences on stem cell transplant outcomes
Official title: Effect of SIRPalpha mismatch on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA matched related donor
Funded at University of Tx Md Anderson Can Ctr · NIH-11052538 · Data updated 2026-11-12
This study is looking at how differences in a protein called SIRPα between blood cancer patients and their stem cell donors can affect the success of their transplants, with the goal of finding ways to improve transplant outcomes and help patients live healthier lives.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $81,000 |
| NIH project number | 5R03CA289563-02 |
| Project ID | NIH-11052538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with hematologic malignancies who are undergoing allogeneic HSCT from HLA-matched related donors.
✕Less likely to help
Patients who are not undergoing HSCT or those receiving transplants from unrelated donors may not benefit from this research.
What this research studies
This research investigates how mismatches in a specific protein called SIRPα between donors and recipients affect the success of allogeneic hematopoietic stem cell transplantation (HSCT) for patients with blood cancers. The study aims to understand the role of the innate immune system in recognizing these mismatches and how they influence the risk of complications like graft-versus-host disease (GVHD). By analyzing patient samples and transplant outcomes, the researchers hope to identify factors that could improve transplant success rates and patient survival. This could lead to better matching strategies for donors and recipients in future transplants.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes and reduced complications for patients undergoing stem cell transplants.
How similar studies have gone: Previous research has shown that understanding immune system interactions can significantly impact transplant outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Zou, Jun — University of Tx Md Anderson Can Ctr
- Study coordinator: Zou, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.