Impact of Diet on Symptoms in Hereditary Alpha-Tryptasemia
Official title: Impact of Diet on Symptomatic Hereditary Alpha-Tryptasemia
Funded at Beth Israel Deaconess Medical Center · NIH-11454037 · Data updated 2026-11-12
This study looks at how food and diet affect people with hereditary alpha-tryptasemia and related gut symptoms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $306,533 |
| NIH project number | 1R21AI196617-01A1 |
| Project ID | NIH-11454037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with hereditary alpha-tryptasemia experiencing GI symptoms such as reflux or IBS-like complaints.
✕Less likely to help
Patients without GI symptoms or without HαT-related manifestations may not benefit from dietary-focused findings.
What this research studies
People with hereditary alpha-tryptasemia often have gut and inflammatory symptoms that resemble IBS or reflux. The team will use confocal laser endomicroscopy to watch how the intestinal lining responds to different food triggers. By examining intestinal barrier function and mucosal reactions, the study aims to identify dietary factors that worsen or improve symptoms. Results could guide personalized dietary strategies for symptom relief and better gut health in this condition.
Why it matters
Potential benefit: If successful, patients with HαT could learn which foods to avoid or include to reduce GI symptoms and improve quality of life.
How similar studies have gone: Previous uses of endomicroscopy to link diet and mucosal response in IBS suggest dietary triggers can be identified, though this exact approach in HαT is novel.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Therrien, Amelie — Beth Israel Deaconess Medical Center
- Study coordinator: Therrien, Amelie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.