Impact of adolescent drinking on brain cell communication
Official title: Effects of adolescent ethanol exposure on astrocyte-neuronal crosstalk
Funded at Marshall University · NIH-10809011 · Data updated 2026-11-12
This study looks at how binge drinking during the teenage years affects brain communication, especially between brain cells called astrocytes and neurons, using rats to understand how this might lead to problems with thinking and a higher chance of alcohol issues later in life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | March 15, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $175,750 |
| NIH project number | 5R21AA030086-02 |
| Project ID | NIH-10809011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 12-20 who have experienced binge drinking or are at risk for alcohol use disorders.
✕Less likely to help
Patients who have not engaged in alcohol use or those outside the adolescent age range may not benefit from this research.
What this research studies
This research investigates how binge drinking during adolescence affects the communication between brain cells, particularly focusing on astrocytes and neurons. By using a rat model, the study examines the long-term effects of ethanol exposure on brain structure and function, aiming to uncover the mechanisms behind cognitive deficits and increased risk of alcohol use disorder in adulthood. The researchers will analyze changes in astrocyte behavior and their role in synaptic communication, which is crucial for maintaining healthy brain function. The findings could provide insights into how early alcohol exposure impacts brain development and behavior.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for alcohol use disorders and cognitive impairments related to adolescent drinking.
How similar studies have gone: Previous studies have shown that similar approaches in animal models can yield significant insights into the effects of alcohol on brain development, suggesting potential for success in this research.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Risher, Mary-Louise — Marshall University
- Study coordinator: Risher, Mary-Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.