Immune-targeting treatments for complex regional pain syndrome
Immune modulating therapies to treat complex regional pain syndrome
Researchers are developing immune-focused therapies to reduce pain and inflammation in people with complex regional pain syndrome (CRPS).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11237290 on NIH RePORTER |
What this research studies
This work looks at how immune cells in the blood and affected skin may drive the ongoing pain and sensitivity in CRPS. Scientists will profile types of T cells, including tissue-resident immune cells, and study molecules that keep those cells in the skin. Findings from human samples and laboratory models will guide strategies to change immune activity and lower pain. The goal is to identify specific immune targets that could be turned into new treatments.
Who could benefit from this research
Good fit: People diagnosed with CRPS, especially those with signs of inflammation or recent worsening in an affected limb, would be the most likely candidates to benefit or participate.
Not a fit: Patients whose pain is driven primarily by long-standing nerve damage or central nervous system changes without immune involvement may be less likely to benefit.
Why it matters
Potential benefit: If successful, this could lead to new treatments that lower pain and inflammation in people with CRPS by targeting the immune system.
How similar studies have performed: Prior studies have found immune abnormalities in CRPS and some immune-based approaches show promise, but effective immune-targeted treatments for CRPS are still limited.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ajit, Seena — Drexel University
- Study coordinator: Ajit, Seena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.