Immune responses linked to severe primary dengue in children
Official title: Immune responses associated with severe disease in patients with primary dengue infection
Funded at Emory University · NIH-11406918 · Data updated 2026-11-12
This project studies why some children with their first dengue infection get very sick by looking closely at their immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $520,683 |
| NIH project number | 5R01AI186371-03 |
| Project ID | NIH-11406918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pediatric patients (0-11 years old) with confirmed severe dengue, including those with primary or secondary infection, and who can provide samples.
✕Less likely to help
Children without severe dengue or without access to the study cohorts may not directly benefit.
What this research studies
Researchers will compare immune responses in children with severe primary dengue to those with severe secondary dengue, using samples from well-characterized patient groups in India. The study examines innate immune activity, dengue-specific antibodies, and T cell responses to understand what drives severity in primary infection. By analyzing how immune signals differ between primary and secondary cases, the team aims to identify factors that predict worse disease and inform better management and prevention. The outcomes could guide vaccine development and therapeutic strategies for pediatric dengue patients.
Why it matters
Potential benefit: Understanding the triggers of severe dengue in children could lead to better risk prediction and targeted treatments.
How similar studies have gone: Prior dengue studies have identified antibody and T cell roles in disease severity; this study builds on known mechanisms but focuses on primary severe dengue.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kaja, Murali Krishna — Emory University
- Study coordinator: Kaja, Murali Krishna
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Immune responses linked to severe dengue in children (primary infection)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.