Immune cells and tiny particles that drive systemic autoimmune disease
Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11332648
This project looks for immune-system signals and tiny particles in children and adults with lupus and related autoimmune diseases to help tailor treatments to each person.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11332648 on ClinicalTrials.gov |
What this research studies
Researchers will use advanced immune profiling, cell biology techniques, and nanoparticle analysis to study blood and samples from patients, with an initial focus on children with systemic lupus erythematosus (SLE). The Center combines clinical cohorts, laboratory studies, and new molecular tools to identify malfunctioning pathways and measurable biomarkers. Work includes comparing immune cells and secreted particles between affected patients and controls and developing tests that could track disease activity. Findings will be shared across collaborators to extend insights to adult SLE and other systemic autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates are children with systemic lupus erythematosus and related systemic autoimmune disease patients (and potentially adults with SLE) who can provide clinical information and biological samples.
Not a fit: People without systemic autoimmune diseases or those unwilling/unable to provide samples or attend clinic visits are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this could help doctors match treatments to a patient’s specific immune problems, improving outcomes and reducing unnecessary side effects.
How similar studies have performed: Previous immune-profiling and biomarker studies in lupus have produced useful clues and some promising markers, but truly personalized treatment approaches are still being developed.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PASCUAL, MARIA VIRGINIA — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: PASCUAL, MARIA VIRGINIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases