Immune Cells and Autoimmune Brain Diseases
ThGM Cells in CNS Autoimmunity
This research explores a specific type of immune cell, called ThGM cells, to understand how they contribute to autoimmune diseases affecting the brain and spinal cord, such as multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11105924 on NIH RePORTER |
What this research studies
Our bodies have many types of immune cells, and this project focuses on a newly identified group called ThGM cells. We've noticed that these ThGM cells are more common in the blood and spinal fluid of people with multiple sclerosis compared to healthy individuals. This suggests they might play a key role in causing the brain and spinal cord inflammation seen in autoimmune conditions. We aim to discover where these ThGM cells come from and exactly how they contribute to these diseases.
Who could benefit from this research
Good fit: This foundational research is most relevant to individuals living with autoimmune diseases affecting the central nervous system, such as multiple sclerosis.
Not a fit: Patients seeking immediate new treatments may not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target and treat autoimmune diseases that affect the brain and spinal cord, potentially offering relief for conditions like multiple sclerosis.
How similar studies have performed: This research explores a newly identified type of immune cell, making this approach relatively novel and less explored in previous studies.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Rostami, A.m. — Thomas Jefferson University
- Study coordinator: Rostami, A.m.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.