Immune and metabolic signs of Valley Fever outcomes
Immune and metabolic correlates of Coccidioides disease spectrum and outcomes
This project looks for immune and metabolic signals in people with Valley Fever to help predict who will have mild, severe, or long-lasting infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11257671 on NIH RePORTER |
What this research studies
If you have Valley Fever, researchers will analyze your blood and other clinical samples to look for immune and metabolic patterns linked to mild, severe, or persistent infection. They will run detailed immune tests and metabolomic profiling on samples from large patient cohorts and compare results across different clinical outcomes. The team will also use mouse models to study how those human immune and metabolic changes drive worse disease and combine all data to build a biosignature that could predict future progression. This work uses existing clinical sample collections and databases at UC Davis and UCSF and applies lab and computational analyses to find practical markers.
Who could benefit from this research
Good fit: Adults diagnosed with Coccidioides (Valley Fever), including acute, chronic, or disseminated cases, who can provide blood or other clinical samples and share medical records.
Not a fit: People without Coccidioides infection or those unable to give samples or clinical information are unlikely to benefit directly from this work.
Why it matters
Potential benefit: It could help doctors predict which patients with Valley Fever will worsen or have prolonged illness so treatment can be started or tailored earlier.
How similar studies have performed: Early studies and the team's preliminary data have shown immune and metabolic differences in Valley Fever, but a clinically validated predictive biosignature has not yet been established.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Dandekar, Satya — University of California, San Francisco
- Study coordinator: Dandekar, Satya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.