Immune activity around glioblastoma and how treatment changes it
Dissecting Orchestrated Immune Responses to Glioblastoma within the Native Tissue Microenvironment to Improve Treatment Outcomes
Researchers will look at tumor and immune cells from glioblastoma patients and mouse models to learn how standard treatments change them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11332986 on NIH RePORTER |
What this research studies
If you take part, researchers will examine tumor tissue from people with glioblastoma and from mouse models to see which tumor and immune cells live in different parts of the tumor. They will use single-cell sequencing and spatial methods to identify how cells differ by location and how they change during disease progression and treatment. Samples will include archived human tumor tissue and mouse tumors treated with standard care (radiation, temozolomide, dexamethasone) to compare before-and-after effects. The aim is to map how treatment reshapes the tumor environment and point to better ways to overcome treatment resistance.
Who could benefit from this research
Good fit: Ideal candidates are people with glioblastoma who can provide tumor tissue (fresh or archival) or who receive care at a center able to send samples to the research team.
Not a fit: People without glioblastoma or those unable to provide tissue samples are unlikely to directly benefit, and findings are not likely to change individual treatment immediately.
Why it matters
Potential benefit: If successful, this work could reveal treatment-resistant cell types and suggest new targets to improve outcomes for people with glioblastoma.
How similar studies have performed: Previous single-cell and spatial studies have mapped cell types in GBM, but combining location-based profiling with how cells evolve through standard treatment is relatively new.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Charest, Alain — Beth Israel Deaconess Medical Center
- Study coordinator: Charest, Alain
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.