ImmGen Consortium: mapping immune gene activity with AI and advanced sequencing
Official title: ImmGen Consortium
Funded at Harvard Medical School · NIH-11422523 · Data updated 2026-11-12
A collaboration of 25 immunology and computational biology labs is using AI and cutting-edge sequencing to map how immune cells express genes and regulate them across all cell types, making a rich public resource for researchers and clinicians.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,999,706 |
| NIH project number | 1R24AI201122-01 |
| Project ID | NIH-11422523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a clinical trial; applicable to future patients through translational discoveries and therapies informed by the atlas.
✕Less likely to help
If the research findings do not translate into specific treatments, direct patient benefit may be limited in the near term.
What this research studies
This project brings together multiple labs to create a comprehensive atlas of immune cell gene expression and regulation. They will use AI-powered analyses, long-read sequencing, spatial transcriptomics, and integrated single-cell data to build a detailed, publicly accessible resource. The work aims to reveal how immune cells differ across tissues and during immune responses, potentially guiding new therapies. The initiative emphasizes scalable data pipelines and evolving machine learning methods to interpret complex regulatory networks. The outcomes could enable researchers and clinicians to better understand immune function and disease mechanisms.
Why it matters
Potential benefit: If successful, patients could benefit from faster insights into immune-related diseases and more precise targets for therapies.
How similar studies have gone: Past ImmGen efforts have produced a valuable public atlas; this project expands capabilities with newer technologies and AI.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Benoist, Christophe O. — Harvard Medical School
- Study coordinator: Benoist, Christophe O.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.