Imaging reactive oxygen species activity in the body
PET Tracers for Imaging ROS Activity
This study is testing a new imaging tool to help doctors see and understand inflammation in the lungs and brain caused by diseases like cancer and lung injuries, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10914211 on NIH RePORTER |
What this research studies
This research focuses on developing a new PET tracer, {68Ga}Galuminox, to visualize and monitor reactive oxygen species (ROS) activity, which plays a crucial role in various diseases, including lung injuries and cancer. The study aims to assess the effectiveness of this tracer in detecting inflammation in the lungs and other organs, providing insights into conditions like acute respiratory distress syndrome and cancer metastasis. Additionally, a new probe, {18F}SLN128, is being designed to penetrate the blood-brain barrier for imaging ROS in the brain, which could enhance our understanding of neurological diseases. Patients may benefit from improved diagnostic tools that can lead to better-targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals suffering from conditions related to oxidative stress, such as acute lung injury, Alzheimer's disease, or certain cancers.
Not a fit: Patients with conditions not related to oxidative stress or those who do not meet the specific criteria for imaging studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advanced imaging techniques that improve the diagnosis and treatment of diseases associated with oxidative stress.
How similar studies have performed: Previous research has shown promise in using PET tracers for imaging inflammation and oxidative stress, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Sharma, Vijay — Washington University
- Study coordinator: Sharma, Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.