Identifying patients at risk for autoimmune diseases based on antinuclear antibodies
Predicting risk of systemic autoimmune disease in patients with positive antinuclear antibodies
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11051886
This study is looking to help doctors understand what a positive antinuclear antibody (ANA) test result really means for patients, so they can quickly identify those who might be at higher risk for autoimmune diseases and get them the right care faster.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11051886 on ClinicalTrials.gov |
What this research studies
This research aims to develop risk models that help healthcare providers determine the significance of positive antinuclear antibodies (ANA) in patients. Since a positive ANA can indicate autoimmune disease but is also common in healthy individuals, the study seeks to identify which patients are at high risk for developing autoimmune conditions. By utilizing electronic health record (EHR) data, the research will create tailored risk assessments to facilitate timely referrals to specialists and improve patient outcomes. The ultimate goal is to reduce the time it takes for patients to receive a diagnosis and appropriate treatment for autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have tested positive for antinuclear antibodies and may be at risk for developing autoimmune diseases.
Not a fit: Patients who do not have positive antinuclear antibodies or those who already have a diagnosed autoimmune disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment for patients at risk of autoimmune diseases, potentially reducing morbidity and mortality associated with these conditions.
How similar studies have performed: Previous research has successfully developed risk models using electronic health records, indicating that this approach has potential for success.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARNADO, APRIL LYNN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: BARNADO, APRIL LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury