Identifying new risk factors and treatments for carotid artery narrowing
Official title: Leveraging the Genetics of carotid stenosis for identifying novel risk factors and therapeutic opportunities
Funded at Philadelphia VA Medical Center · NIH-10863814 · Data updated 2026-11-12
This study is looking into how our genes might affect carotid stenosis, a condition that can increase the risk of strokes, to help find better ways to prevent and treat it for people with heart-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01BX006159-02 |
| Project ID | NIH-10863814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of carotid artery narrowing or those at risk for atherosclerotic cardiovascular disease.
✕Less likely to help
Patients without any cardiovascular risk factors or those who do not have carotid artery diseases may not benefit from this research.
What this research studies
This research investigates the genetic factors associated with carotid stenosis, a condition that can lead to serious cardiovascular events like strokes. By analyzing data from the VA Million Veteran Program, the study aims to uncover specific biological markers and risk factors that contribute to this condition. The approach includes advanced techniques such as natural language processing to analyze large datasets, which may lead to more personalized prevention and treatment strategies for patients with atherosclerotic cardiovascular disease.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for patients at risk of carotid artery diseases.
How similar studies have gone: Previous genetic studies in related cardiovascular conditions have shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Damrauer, Scott Michael — Philadelphia VA Medical Center
- Study coordinator: Damrauer, Scott Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.