Identifying new genetic factors for coronary artery disease related to cholesterol levels
Official title: Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease
Funded at Broad Institute, INC. · NIH-10906227 · Data updated 2026-11-12
This study is looking at the genes that might cause heart problems in people with familial hypercholesterolemia, a condition that raises cholesterol levels and can lead to early heart disease, to help find more people at risk and improve how we screen and treat them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $164,980 |
| NIH project number | 5K99HL169733-02 |
| Project ID | NIH-10906227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of high cholesterol or early heart disease, particularly those suspected of having familial hypercholesterolemia.
✕Less likely to help
Patients without a genetic predisposition to high cholesterol or coronary artery disease may not benefit from this research.
What this research studies
This research focuses on understanding the genetic basis of coronary artery disease (CAD), particularly in individuals with familial hypercholesterolemia (FH), a condition that leads to high cholesterol and early heart disease. The study aims to discover new genes and mechanisms that contribute to FH by analyzing whole genome sequences. By improving genetic diagnostic criteria, the research seeks to identify more individuals who may be at risk for CAD but are currently undiagnosed. This could lead to better screening and treatment options for those affected.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for individuals at risk of coronary artery disease.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to cholesterol and heart disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Koyama, Satoshi — Broad Institute, INC.
- Study coordinator: Koyama, Satoshi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.