Identifying immune responses to double-stranded RNA
Systematic identification and characterization of immunogenic double-stranded RNAs
This study is looking at how our immune system tells the difference between harmful viruses and our own body’s RNA, focusing on a protein called ADAR1 that helps prevent autoimmune issues, and it hopes to find new ways to treat autoimmune disorders that affect people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11009046 on NIH RePORTER |
What this research studies
This research investigates how the immune system recognizes double-stranded RNA (dsRNA) and differentiates between harmful viral RNA and the body's own RNA. It focuses on a protein called ADAR1 that modifies cellular dsRNA to prevent autoimmune reactions. By studying mouse models and human diseases, the research aims to uncover the mechanisms behind autoimmune conditions linked to dsRNA and improve understanding of related inflammatory diseases. Patients may benefit from insights that could lead to new treatments for autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases such as Aicardi-Goutieres Syndrome, Inflammatory Bowel Disease, Multiple Sclerosis, and other related conditions.
Not a fit: Patients with autoimmune diseases not linked to dsRNA mechanisms or those without any autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases by enhancing the body's ability to distinguish between self and non-self RNA.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA editing in autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.