Identifying immune responses to double-stranded RNA
Official title: Systematic identification and characterization of immunogenic double-stranded RNAs
Funded at Stanford University · NIH-11009046 · Data updated 2026-11-12
This study is looking at how our immune system tells the difference between harmful viruses and our own body’s RNA, focusing on a protein called ADAR1 that helps prevent autoimmune issues, and it hopes to find new ways to treat autoimmune disorders that affect people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 8, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $700,277 |
| NIH project number | 5R01AI182437-02 |
| Project ID | NIH-11009046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases such as Aicardi-Goutieres Syndrome, Inflammatory Bowel Disease, Multiple Sclerosis, and other related conditions.
✕Less likely to help
Patients with autoimmune diseases not linked to dsRNA mechanisms or those without any autoimmune conditions may not benefit from this research.
What this research studies
This research investigates how the immune system recognizes double-stranded RNA (dsRNA) and differentiates between harmful viral RNA and the body's own RNA. It focuses on a protein called ADAR1 that modifies cellular dsRNA to prevent autoimmune reactions. By studying mouse models and human diseases, the research aims to uncover the mechanisms behind autoimmune conditions linked to dsRNA and improve understanding of related inflammatory diseases. Patients may benefit from insights that could lead to new treatments for autoimmune disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases by enhancing the body's ability to distinguish between self and non-self RNA.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA editing in autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.