Identifying harmful T cells in patients with membranous nephropathy.
High-throughput identification and transcriptional analysis of autoreactive T cells in individuals with membranous nephropathy.
['FUNDING_R21'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10908643
This study is looking at how certain immune cells called T cells behave in people with membranous nephropathy, a kidney disease, to help find better ways to understand and treat the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10908643 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of autoreactive T cells in membranous nephropathy, a kidney disease caused by specific antibodies. Researchers will develop a method to capture and analyze the T cell receptors from patients, which will help identify T cells that react to the phospholipase 2A receptor, a key target in this condition. By using advanced sequencing techniques, the study aims to create a comprehensive library of these T cell receptors for further functional analysis. This could lead to new insights into the disease and potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with membranous nephropathy.
Not a fit: Patients with other forms of kidney disease unrelated to membranous nephropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with membranous nephropathy by targeting harmful T cells.
How similar studies have performed: Previous research has shown that targeting autoreactive T cells can be effective in other autoimmune diseases, suggesting potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRAVEDI, PAOLO — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CRAVEDI, PAOLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases