Identifying harmful T cells in patients with membranous nephropathy.
Official title: High-throughput identification and transcriptional analysis of autoreactive T cells in individuals with membranous nephropathy.
Funded at Icahn School of Medicine at Mount Sinai · NIH-10908643 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells behave in people with membranous nephropathy, a kidney disease, to help find better ways to understand and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $209,500 |
| NIH project number | 5R21AI178021-02 |
| Project ID | NIH-10908643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with membranous nephropathy.
✕Less likely to help
Patients with other forms of kidney disease unrelated to membranous nephropathy may not benefit from this research.
What this research studies
This research focuses on understanding the role of autoreactive T cells in membranous nephropathy, a kidney disease caused by specific antibodies. Researchers will develop a method to capture and analyze the T cell receptors from patients, which will help identify T cells that react to the phospholipase 2A receptor, a key target in this condition. By using advanced sequencing techniques, the study aims to create a comprehensive library of these T cell receptors for further functional analysis. This could lead to new insights into the disease and potential treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with membranous nephropathy by targeting harmful T cells.
How similar studies have gone: Previous research has shown that targeting autoreactive T cells can be effective in other autoimmune diseases, suggesting potential success for this approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Cravedi, Paolo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cravedi, Paolo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.