Identifying gut and blood bacteria to predict infections in kidney transplant patients
Microbial Biomarkers for Diagnosing and Predicting Infections in Kidney Transplant Recipients
This study is looking for better ways to spot and predict infections in people who have had a kidney transplant by checking for certain markers in their stool, blood, and urine, which could help keep them healthier and reduce complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11094873 on NIH RePORTER |
What this research studies
This research aims to develop new methods for diagnosing and predicting infections in kidney transplant recipients by analyzing microbial biomarkers found in stool, blood, and urine. The study will focus on creating assays that measure short-chain fatty acids in feces and cell-free DNA in blood and urine, which may indicate the risk of infections. By understanding the relationship between these microbial markers and infection rates, the research seeks to improve patient outcomes and reduce complications associated with immunosuppression. The approach is based on previous findings that link specific bacteria to lower infection rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are undergoing immunosuppressive therapy.
Not a fit: Patients who have not undergone kidney transplantation or those who are not on immunosuppressive therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and prevention of infections in kidney transplant patients, significantly improving their health outcomes.
How similar studies have performed: Previous pilot studies have shown promising results in using microbial biomarkers for predicting infections, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Lee, John Richard — Weill Medical Coll of Cornell Univ
- Study coordinator: Lee, John Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.