Identifying genetic variations that affect disease progression
A Functional Genomics Platform for the de novo Identification of Disease-relevant Alleles
This study is looking at how natural differences in our genes can affect the way diseases like HIV progress, and it aims to find out which of these genetic variations might help us create better treatments and understand risks for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11056142 on NIH RePORTER |
What this research studies
This research focuses on understanding how natural genetic variations in humans can influence the progression of diseases, particularly those related to HIV. By developing a new functional genomics platform, the researchers aim to engineer and analyze these genetic variants to identify those that are relevant to disease outcomes. This approach utilizes advanced gene editing technologies to recreate human genetic variations in a controlled environment, allowing for detailed study of their effects on disease. Patients may benefit from insights gained that could lead to better-targeted treatments and risk assessments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations that may influence their response to HIV or other infectious diseases.
Not a fit: Patients without any genetic variations relevant to HIV progression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for diseases like HIV.
How similar studies have performed: Previous research has shown success in identifying genetic variants related to HIV, but this approach aims to expand on those findings in a novel way.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hultquist, Judd F — Northwestern University at Chicago
- Study coordinator: Hultquist, Judd F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.