Identifying genetic markers to predict disease progression in chronic hypersensitivity pneumonitis
Development and Validation of a Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis
This study is looking at how certain genes in your blood might help doctors predict how chronic hypersensitivity pneumonitis will change over time, so they can better tailor treatments just for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10688186 on NIH RePORTER |
What this research studies
This research aims to develop a genetic profile that can help predict how chronic hypersensitivity pneumonitis (HP) will progress in patients. By analyzing blood samples from individuals with chronic HP, researchers will identify specific gene expression patterns associated with disease progression. This approach involves both discovering these patterns in a primary group of patients and validating them in a separate group. The goal is to enhance the ability to forecast patient outcomes and tailor treatment strategies accordingly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic hypersensitivity pneumonitis, particularly those without a known inciting antigen exposure.
Not a fit: Patients with hypersensitivity pneumonitis who have a known inciting antigen exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic tools for patients with chronic hypersensitivity pneumonitis, allowing for more personalized and effective treatment plans.
How similar studies have performed: Previous research has shown promise in using genetic signatures to predict disease outcomes in other chronic conditions, suggesting potential success for this approach.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Fernandez, Evans — National Jewish Health
- Study coordinator: Fernandez, Evans
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.