Identifying genetic factors to prevent repeated heart attacks
Discovery and Application of Germline and Somatic Mutations for Risk Prediction and Personalized Therapy to Prevent Recurrent Myocardial Infarction
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10869926
This study is looking at how your genes might affect your chances of having more heart attacks after your first one, and if you join, you could get genetic testing to learn more about your own heart health and treatment options.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10869926 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic differences that may contribute to recurrent myocardial infarction (MI) compared to initial heart attacks. By analyzing genetic data from patients who have experienced an MI, the study aims to discover specific mutations that could help predict the risk of future heart attacks. The approach involves leveraging existing data from multiple cardiovascular clinical trials to identify these genetic markers and their potential applications in personalized therapy. Patients participating in this research may undergo genetic testing to better understand their risk factors and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have survived a myocardial infarction and are at risk for recurrent events.
Not a fit: Patients who have not experienced a myocardial infarction or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized therapies that significantly reduce the risk of recurrent heart attacks in patients.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to initial coronary artery disease, but this specific focus on recurrent MI is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARSTON, NICHOLAS — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: MARSTON, NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases