Identifying genetic factors that influence serious mental illness
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental Illness
This study is looking at how certain genetic differences might increase the risk of serious mental illnesses, with the hope that understanding these connections can lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10734052 on NIH RePORTER |
What this research studies
This research investigates the genetic variations linked to serious mental illnesses by analyzing multi-omics data, which includes genomic, transcriptomic, and proteomic information. The goal is to understand how specific genetic markers, known as single nucleotide polymorphisms (SNPs), contribute to the risk of developing psychiatric disorders. By integrating various biological data types, the study aims to uncover the mechanisms that connect genetic risk factors to mental health outcomes, potentially leading to more targeted treatments. Patients may benefit from insights into their genetic predispositions and improved therapeutic strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with serious mental health disorders.
Not a fit: Patients with mild or transient mental health issues may not receive significant benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with serious mental illnesses.
How similar studies have performed: Previous studies have shown promise in linking genetic variations to psychiatric disorders, but this approach aims to provide deeper insights through a multi-omics perspective, making it a novel endeavor.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Macdonald, Matthew L — University of Pittsburgh at Pittsburgh
- Study coordinator: Macdonald, Matthew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.