Identifying genetic factors that affect susceptibility to Staphylococcus aureus infections
HLA Fine Mapping to Elucidate S. aureus Susceptibility
This study is looking at how certain genes might affect the risk of getting a serious infection called Staphylococcus aureus bacteremia, and it's for patients who want to help us understand more about how their genetics could influence their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10911298 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations in the Human Leukocyte Antigen (HLA) class II region influence the risk of developing Staphylococcus aureus bacteremia (SAB), a serious bacterial infection. By analyzing a large cohort of patients, including those of African American and European descent, the study aims to pinpoint genetic markers that could predict susceptibility to this infection. The research employs advanced genotyping techniques and utilizes a unique collection of patient DNA and bacteria samples to enhance understanding of these genetic determinants. Patients may be asked to provide samples and participate in assessments to help identify these critical genetic factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of Staphylococcus aureus infections, particularly those of African American descent.
Not a fit: Patients who do not have a history of Staphylococcus aureus infections or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for Staphylococcus aureus infections.
How similar studies have performed: Previous studies have shown significant associations between HLA class II variants and susceptibility to Staphylococcus aureus infections, indicating a promising avenue for further exploration.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Fowler, Vance G. — Duke University
- Study coordinator: Fowler, Vance G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.