Identifying genes that influence neurodegeneration in Alzheimer's and related diseases
A multiplexable in vivo perturbation toolkit to identify genes affecting neurodegeneration in a model of synucleinopathy
This study is looking at how certain genes might play a role in brain diseases like Alzheimer's and Parkinson's, using mice to find out which genes help protect brain cells, with the hope of discovering new treatments that could improve life for people with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10790626 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to neurodegeneration in conditions like Alzheimer's disease and Parkinson's disease with dementia. Using advanced techniques such as CRISPR-Cas9 library screening, the study aims to identify specific genes that affect neuronal survival and resilience in a mouse model of synucleinopathy. By profiling the genetic makeup of neurons, researchers hope to uncover potential targets for new neuroprotective therapies and biomarkers that could improve patient outcomes. The ultimate goal is to develop strategies that could help mitigate the effects of these debilitating diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, Parkinson's disease with dementia, or dementia with Lewy bodies.
Not a fit: Patients with neurodegenerative disorders not related to synucleinopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent neurodegeneration in patients with Alzheimer's and related disorders.
How similar studies have performed: Previous research using CRISPR technology has shown promise in identifying genetic factors in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Przedborski, Serge E — Columbia University Health Sciences
- Study coordinator: Przedborski, Serge E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.