Identifying genes linked to lupus nephritis in specific immune cells
Identifying autoimmune associated genes in patrolling monocytes that promote lupus nephritis
['FUNDING_R21'] · BENAROYA RESEARCH INST AT VIRGINIA MASON · NIH-10873263
This study is looking at how certain immune cells called patrolling monocytes affect kidney problems in people with lupus, especially in communities that are more impacted, like African-Americans, Hispanics, and Asians, to find new ways to treat or prevent these kidney issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BENAROYA RESEARCH INST AT VIRGINIA MASON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10873263 on ClinicalTrials.gov |
What this research studies
This research investigates the role of patrolling monocytes, a type of immune cell, in the development of lupus nephritis, a serious kidney condition associated with systemic lupus erythematosus. The study aims to identify specific genes that contribute to the accumulation of these monocytes in the kidneys, which may lead to new treatment options. By understanding the genetic mechanisms involved, researchers hope to develop targeted therapies that could prevent or treat lupus nephritis more effectively. The research focuses particularly on populations disproportionately affected by this condition, including African-Americans, Hispanics, and Asians.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those who are African-American, Hispanic, or Asian.
Not a fit: Patients with lupus nephritis who do not have systemic lupus erythematosus or those from non-affected ethnic backgrounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively prevent or treat lupus nephritis, improving outcomes for patients.
How similar studies have performed: While there have been advancements in understanding lupus nephritis, targeting patrolling monocytes represents a novel approach that has not yet been extensively tested.
Where this research is happening
SEATTLE, UNITED STATES
- BENAROYA RESEARCH INST AT VIRGINIA MASON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAMERMAN, JESSICA A — BENAROYA RESEARCH INST AT VIRGINIA MASON
- Study coordinator: HAMERMAN, JESSICA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases