Identifying genes linked to addiction using zebrafish genetics.
Exploiting zebrafish genetics to identify genes affecting addiction-related phenotypes.
This study is looking at how certain genes might affect addiction by using zebrafish, which share some genetic traits with humans, to see how they react to nicotine; the goal is to help find out who might be at risk for addiction and to create better treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ/london-Queen Mary& Westfield Coll NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project ID | NIH-10460608 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to addiction by utilizing zebrafish as a model organism. Zebrafish are known for their genetic similarities to humans and their ability to exhibit behaviors related to addiction, such as sensitivity to nicotine. The study aims to identify specific genes that influence addiction-related traits by screening genetically modified zebrafish for their responses to nicotine. By understanding these genetic influences, the research seeks to inform strategies for identifying individuals at risk for addiction and developing targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who may be at risk for addiction or have a history of substance use disorders.
Not a fit: Patients who do not have a history of substance use or are under the age of 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of individuals at risk for addiction and more effective treatment strategies.
How similar studies have performed: Previous research using zebrafish models has shown promise in identifying genetic factors related to addiction, indicating that this approach has potential for success.
Where this research is happening
London, United Kingdom
- Univ/london-Queen Mary& Westfield Coll — London, United Kingdom (Active)
Researchers
- Principal investigator: Brennan, Caroline Helen — Univ/london-Queen Mary& Westfield Coll
- Study coordinator: Brennan, Caroline Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.