Identifying dangerous melanomas at diagnosis
Identification of Lethal Melanomas at the Time of Diagnosis
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10825538
This study is looking at how to better predict which melanoma patients might face serious risks right when they're diagnosed, so that those who need early treatment can get it, while also helping others avoid unnecessary treatments if their cancer is less aggressive.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10825538 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the prediction of lethal melanoma at the time of diagnosis. By analyzing genetic alterations and immune responses in tumor samples, the study aims to identify which patients are at high risk for aggressive melanoma and would benefit from early treatment. Conversely, it seeks to find profiles of tumors that indicate a low risk of recurrence, allowing some patients to avoid unnecessary and potentially harmful treatments. The research involves testing common mutations in specific genes associated with melanoma outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with melanoma who are at varying stages of the disease.
Not a fit: Patients with non-melanoma skin cancers or those who have already received extensive treatment for melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for melanoma patients, improving outcomes and reducing unnecessary treatments.
How similar studies have performed: Other research has shown promise in using genetic profiling to predict cancer outcomes, suggesting that this approach could be effective.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, NANCY E. — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: THOMAS, NANCY E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Skin Cancer