Identifying brain chemical changes linked to dementia
Official title: Identification of brain metabolomic profiles associated with dementia
Funded at Brigham and Women's Hospital · NIH-11117086 · Data updated 2026-11-12
This study is looking at how changes in brain metabolism might play a role in Alzheimer's and other types of dementia by examining brain tissue from 1,200 people, with the hope of finding new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $826,190 |
| NIH project number | 5R01AG087356-02 |
| Project ID | NIH-11117086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a diagnosis of Alzheimer's Disease or related dementias, as well as those at risk due to metabolic conditions.
✕Less likely to help
Patients with non-Alzheimer's forms of dementia or those without any metabolic risk factors may not benefit from this research.
What this research studies
This research investigates the specific brain metabolic pathways that may contribute to Alzheimer's Disease and related dementias. By analyzing postmortem brain tissue from 1,200 individuals, the study aims to uncover how metabolic dysregulation affects cognitive decline. The approach combines clinical, neuropathologic, and genomic data to provide a comprehensive understanding of the biochemical changes associated with dementia. This could lead to new targets for preventive and therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding metabolic profiles in dementia, but this study aims to fill critical gaps with a larger sample size and deeper analysis.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Li, Jun — Brigham and Women's Hospital
- Study coordinator: Li, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.