Identifying and preventing severe lung complications after stem cell transplants
Predicting and Preventing Acute Respiratory Distress Syndrome after Hematopoietic Stem Cell Transplantation
This study is looking to help patients who are getting a stem cell transplant by finding ways to predict and prevent a serious lung problem called acute respiratory distress syndrome (ARDS), so they can have a smoother recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10909914 on NIH RePORTER |
What this research studies
This research focuses on improving outcomes for patients undergoing hematopoietic stem cell transplantation (HSCT) by developing methods to predict and prevent acute respiratory distress syndrome (ARDS), a serious lung complication that can occur post-transplant. The study aims to create a risk-prediction model that identifies patients at high risk for ARDS using various pre- and post-transplant factors. Additionally, it will explore the biological mechanisms behind ARDS through metabolomics, which involves analyzing metabolites in the body to understand different patient responses. By addressing these critical gaps, the research seeks to enhance patient care and reduce the incidence of ARDS following HSCT.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled to undergo hematopoietic stem cell transplantation who may be at risk for developing acute respiratory distress syndrome.
Not a fit: Patients who are not undergoing hematopoietic stem cell transplantation or those who have pre-existing severe lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the occurrence of ARDS in patients undergoing stem cell transplants, leading to better survival rates and improved quality of life.
How similar studies have performed: Previous research has shown promise in using risk-prediction models and metabolomics to address similar complications in other patient populations, indicating potential for success in this novel approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yadav, Hemang — Mayo Clinic Rochester
- Study coordinator: Yadav, Hemang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.