Identifying a key gene that regulates brain function and cognition.
A multidisciplinary approach identifying PDZ-RhoGEF (ARHGEF11) as a critical regulator of synapses and cognition
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11051883
This study is looking at how a gene called ARHGEF11 affects thinking and memory in the brain, which could help us understand cognitive issues in people with conditions like bipolar disorder and lead to new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11051883 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific gene, ARHGEF11, in regulating cognitive abilities and synaptic function in the brain. By examining how this gene interacts with microRNAs and its impact on learning and memory, the study aims to uncover the biological mechanisms behind cognitive impairments. The approach includes genetic analysis and biochemical methods to understand the gene's function in the cerebral cortex, particularly in relation to conditions like bipolar disorder. Patients may benefit from insights that could lead to new treatments for cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with bipolar disorder or those experiencing cognitive decline.
Not a fit: Patients with cognitive impairments not related to the mechanisms being studied, such as those with purely structural brain injuries, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognitive function in individuals with cognitive impairments.
How similar studies have performed: Previous research has shown promise in understanding the genetic basis of cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAHILL, MICHAEL EDWARD — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: CAHILL, MICHAEL EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bipolar affective disorder, bipolar disease, Bipolar Disorder